Molecular and cellular radiobiological effects of Auger emitting radionuclides

Cellular dosimetry of beta emitting radionuclides-antibody conjugates for radioimmunotherapy

Introduction: The choice of optimal radionuclides for radioimmunotherapy depends on several factors, especially the radionuclide and antibody. The dosimetric characteristics of a non-internalizing and an internalizing monoclonal antibody (MAb) labeled with beta emitting radionuclides were investigated. Methods: Using Geant4-DNA Monte Carlo simulation, we ...

Dosimetry of Auger-Electron-Emitting Radionuclides

Monte Carlo evaluation of Auger electron-emitting theragnostic radionuclides

Monte Carlo Evaluation of Auger Electron-Emitting Theranostic Radionuclides.

UNLABELLED Several radionuclides used in medical imaging emit Auger electrons, which, depending on the targeting strategy, either may be exploited for therapeutic purposes or may contribute to an unintentional mean absorbed dose burden. In this study, the virtues of 12 Auger electron-emitting radionuclides were evaluated in terms of cellular S values in concentric and eccentric cell-nucleus arr...

Assessment and management of risks associated with exposures to Auger- and beta-emitting radionuclides